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A study of serum biomarkers associated with relapse of cervical cancer
Louise Bohr Mordhorst1, Bengt Sorbe, Cecilia Ahlin
1Department of Oncology, Örebro University Hospital, SE-701 85 Örebro, Sweden. louise.bohr-mordhorst@orebroll.se
Background/Aim:
To discover candidate protein biomarkers in the serum of patients with cervical cancer that differentiate between patients with relapse from those who are tumor-free after primary treatment with (platinum-based chemo-) radiation.
Patients And Methods:
Surface-enhanced laser desorption/ionization time-of-flight mass spectrometry (SELDI-TOF-MS) with cation exchange (CM10) and hydrophobic/reverse-phase (H50) was used to examine 44 serum samples from patients with advanced cervical cancer, primarily treated with (platinum-based chemo-) radiation.
Results:
Ten candidate biomarkers were identified in the serum of 34 patients. Six candidate markers were elevated in patients with no relapse and four were elevated in patients with relapse [p=0.007-0.11; area under the curve (AUC)=0.70-0.75]. Masses of candidate biomarkers ranged from 2,022 to 116,165 Da.
Conclusion:
Patients with relapse from primary advanced cervical cancer exhibit different serum protein expression profiles from those with no relapse.
