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Updated: May 16, 2026
09:16
Orthotopic Small Bowel Transplantation in Rats
Published on: November 6, 2012
[Intestinal transplant: in what phase are we?].
A M Andrés Moreno1, E Ramos, F Hernández
1Departamento de Cirugía Pediátrica, Sección de Trasplantes Digestivos, Hospital Infantil La Paz, Madrid. aneandresmo@hotmail.com
Summary
Pediatric intestinal transplantation offers a viable solution for irreversible intestinal failure, enabling patients to achieve a normal life. Continuous follow-up is crucial for managing immunological complications and improving long-term outcomes.
Area of Science:
- Pediatric surgery
- Transplantation immunology
- Gastroenterology
Context:
- Intestinal transplantation is a complex procedure for children with irreversible intestinal failure.
- The program's evolution from 1997 to 2009 involved 52 transplants in 46 children.
- Indications included short gut syndrome, dismotility, and intractable diarrhea.
Purpose:
- To analyze the evolution and outcomes of a pediatric small bowel transplantation program.
- To evaluate patient and graft survival, quality of life, and complications.
- To assess the impact of center experience on transplant results.
Summary:
- Fifty-two intestinal transplants (isolated bowel, combined liver-intestine, multivisceral) were performed in 46 children.
- Overall 5-year patient survival was 65.2% (graft survival 51.7%), with improved survival rates in recent years (2006-2008).
- Long-term follow-up showed 59% of patients alive, off total parenteral nutrition (TPN), and enjoying a good quality of life.
Impact:
- Intestinal transplantation is a consolidated option for irreversible intestinal failure, facilitating a normal life for pediatric patients.
- Improved surgical techniques and immunosuppression management have enhanced transplant outcomes.
- Close post-transplant monitoring is essential for early diagnosis and management of immunological complications.
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