[Role of alimentary factor in gastroesophageal reflux disease pathogenesis and treatment]

The aim of the study was to evaluate the impact of meal volume, weight change, excessive weight, and caloric content of the ration on disease's manifestation and progression from data presented in the published scientific literature. Systematic review in PubMed/Medline databased was performed with key words: food, dietary patterns, nutrients, nutrition, meal volume, calorie in combination with gastroesophageal reflux and GERD. 113 articles were found and 29 of them were selected according to the following criteria: the article should contain data of clinical observations, or to be a result of meta-analysis; study group characteristic, study design, and results should have been available for the analysis. The review contains data concerning influence of body mass index, its change; meal volume and caloric content of the ration on clinical manifestations of GERD. The dietotherapy recommendations for this illness include exclusion of overeating, limitation in use of high-caloric foods, increased protein content in diet, the adherence of 3-4 meals daily, with the last meal at 2-3 hours before sleep. However, the majority of the recommendations on the use of dietary nutrition is mainly based on the empiric experience, not on scientific data, and that doesn't allow to prepare reasonable recommendations for changing the diet of the patients with GERD. There is a need for prospective studies of influence of diet correction on course of the disease.