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Related Experiment Videos

Urography with spasmolytics.

J Kinnunen1, O Saarinen, J Ahovuo

  • 1Department of Diagnostic Radiology, Surgical Hospital, Helsinki, Finland.

Rontgen-Blatter; Zeitschrift Fur Rontgen-Technik Und Medizinisch-Wissenschaftliche Photographie
|January 1, 1990
PubMed
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Glucagon and hyoscine butylbromide (Buscopan) were evaluated for their effects on urography. Buscopan showed marginal improvement in ureteral visualization in the prone position, while glucagon worsened pyelocalyceal visualization.

Area of Science:

  • Radiology
  • Urology
  • Pharmacology

Background:

  • Routine urography with abdominal compression is a standard diagnostic procedure.
  • Optimizing visualization of the pyelocalyceal system and ureters is crucial for accurate diagnosis.
  • Pharmacological agents are sometimes used to enhance imaging quality.

Purpose of the Study:

  • To compare the effects of glucagon, hyoscine butylbromide (Buscopan), and placebo on the visualization of the pyelocalyceal systems and ureters during routine urography with abdominal compression.
  • To determine if these agents improve image quality and diagnostic accuracy.

Main Methods:

  • A double-blind, randomized trial was conducted involving 189 kidneys and ureters.
  • Participants received either glucagon (1 mg i.v.), hyoscine butylbromide (Buscopan, 20 mg i.v.), or a placebo.

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  • Urography was performed with abdominal compression, and visualization of the urinary tract was assessed.

    • Main Results:

    • Ureteral visualization was significantly better in the supine position compared to the prone position.
    • In the prone position, Buscopan marginally improved ureteral visualization compared to placebo or glucagon.
    • Neither Buscopan nor glucagon significantly improved overall pyeloureteral visualization.
    • Glucagon significantly worsened pyelocalyceal visualization compared to placebo and marginally worsened it compared to Buscopan.

    Conclusions:

    • Abdominal compression and patient positioning (supine vs. prone) significantly impact ureteral visualization in urography.
    • Hyoscine butylbromide (Buscopan) may offer a marginal benefit for ureteral visualization in the prone position.
    • Glucagon appears detrimental to pyelocalyceal visualization and is not recommended for enhancing urography quality.