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Optimization of Synthetic Proteins: Identification of Interpositional Dependencies Indicating Structurally and/or Functionally Linked Residues
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Deciphering the message in protein sequences: tolerance to amino acid substitutions

J U Bowie1, J F Reidhaar-Olson, W A Lim

  • 1Department of Biology, Massachusetts Institute of Technology, Cambridge 02139.

Science (New York, N.Y.)
|March 16, 1990
PubMed
Summary

Comparing protein sequences reveals how genetic code degeneracy impacts protein structure and function. Understanding this relationship aids in predicting protein folding and biological activity.

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