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Related Experiment Video

Updated: May 16, 2026

Mouse Round Spermatid Injection

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Published on: January 26, 2024

ICSI cycle outcomes in oligozoospermia.

I I Arikan¹, B Demir, G Bozdag

¹Department of Gynecology and Obstetrics, Zonguldak Karaelmas University, Faculty of Medicine, Zonguldak, Turkey. driarikan@hotmail.com

Clinical and Experimental Obstetrics & Gynecology

|November 20, 2012

Summary

Lower sperm concentration negatively impacts fertilization rates in Intracytoplasmic Sperm Injection (ICSI) cycles. However, embryo quality and pregnancy success remain unaffected across varying sperm concentrations.

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Area of Science:

Reproductive Medicine
Andrology
Infertility Treatment

Background:

Sperm concentration is a key factor in male fertility.
Intracytoplasmic Sperm Injection (ICSI) is a common treatment for male factor infertility.
The specific impact of varying sperm concentrations on ICSI outcomes requires further clarification.

Purpose of the Study:

To investigate the isolated effect of sperm concentration on fertilization, embryo quality, and pregnancy rates in ICSI cycles.
To determine if lower sperm counts adversely affect ICSI success.
To analyze outcomes across different ranges of sperm concentration.

Main Methods:

Retrospective analysis of 560 ICSI cycles for male factor infertility.
Patients were categorized into four groups based on sperm concentration ( <1x10^6, 1-5x10^6, 5-10x10^6, 10-20x10^6).
Comparison of fertilization rates, embryo quality, and clinical pregnancy rates among the groups.

Main Results:

Fertilization rates were significantly lower in groups with sperm concentrations below 10x10^6 compared to the highest concentration group (p<0.05).
No significant differences were observed in ovarian response, embryo quality, or clinical pregnancy rates among the four groups.
The first three groups, representing lower sperm concentrations, showed comparable results to each other.

Conclusions:

Reduced sperm concentration has a detrimental effect on fertilization rates during ICSI.
Severe and extremely severe oligozoospermia are particularly associated with lower fertilization outcomes.
Sperm concentration does not appear to influence embryo quality or clinical pregnancy rates in ICSI cycles.