Related Experiment Video
Updated: May 16, 2026

The Immediate Partial Removal of Cumulus-Oocyte Complexes: A Refined Approach for Rapid Observation of In Vitro Fertilization
Published on: October 18, 2024
Modified repeated intracyclic clomiphene citrate therapy after conventional clomiphene therapy
M Kawamura1, A Suzuki, R Kanda
1Department of Obstetrics and Gynecology, Kohseichuo General Hospital, Tokyo, Japan. mkawamura@kohseichuo.jp
Purpose Of Investigation:
We compared modified repeated intracyclic clomiphene citrate therapy (RICCT) to gonadotropin therapy to determine whether this modified regimen was an effective alternative after conventional clomiphene therapy.
Methods:
Patients with ovulation disorder received treatment with modified RICCT and gonadotropin, and ovulation, pregnancy, total drug cost, and adverse effects were compared.
Results:
Among a total of 16 patients, 14 successfully ovulated after modified RICCT and 11 ovulated after gonadotropin therapy; two did not respond to either therapy. The total drug cost was US $36.3+/-17.9 for modified RICCT, which was significantly lower than the cost of gonadotropin therapy, US $213.9+/-100.4 (p=0.0001).
Conclusions:
Because modified RICCT does not require the discomfort of daily injection and has excellent ovulation-inducing effects, it is a useful treatment after conventional clomiphene therapy.
Related Concept Videos
In Vitro Fertilization
The IVF process begins with ovarian stimulation, during which reproductive endocrinologists prescribe hormonal medications to stimulate the ovaries to produce multiple eggs instead of the single...
Meiosis II
Ovarian Cycle
Intrauterine Drug Delivery Systems
