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Generalized flare of pustular psoriasis induced by PEGylated interferon-α2b therapy for chronic hepatitis C
1Department of Dermatology, National Cheng Kung University Medical College and Hospital, 138 Sheng-Li Road, Tainan, Taiwan.
Abstract:
New onset or exacerbation of psoriasis vulgaris has been reported in a small number of patients after interferon (IFN)-α therapy. Herein, we report a case of generalized flare of pustular psoriasis induced by PEGylated IFN-α2b (PEG-IFN-α2b) in a 59-year-old woman with a 15-year history of pustular psoriasis and chronic hepatitis C. Interferon-α therapy was discontinued and the rash resolved after treatment with cyclosporin and systemic methylprednisolone. The potential side effect of PEG-IFN-α2b in inducing or exacerbating psoriasis should be kept in mind when treating patients with a history of psoriasis or pustular psoriasis.
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