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Related Experiment Video

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Hepatic Glucose Production, Ureagenesis, and Lipolysis Quantified using the Perfused Mouse Liver Model

Hepatic Glucose Production, Ureagenesis, and Lipolysis Quantified using the Perfused Mouse Liver Model

Published on: October 6, 2023

Modeling the hepatic arterial buffer response in the liver.

Harvey Ho¹, Keagan Sorrell, Adam Bartlett

¹Bioengineering Institute, University of Auckland, New Zealand. harvey.ho@auckland.ac.nz

Medical Engineering & Physics

|November 20, 2012

Summary

This study introduces an electrical model of the liver's hepatic arterial buffer response (HABR). The model simulates how arterial flow compensates for portal vein changes, crucial for liver health and transplantation.

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Area of Science:

Physiology
Biomedical Engineering
Computational Biology

Background:

The hepatic arterial buffer response (HABR) is a critical intrinsic liver mechanism regulating blood flow.
Understanding HABR dynamics is essential for liver health and post-transplant outcomes.
Previous models of HABR exist, but simplifications are needed for dynamic analysis.

Purpose of the Study:

To develop a simplified electrical analog model of the hepatic arterial buffer response (HABR).
To simulate the effects of portal vein occlusion on liver blood flow using the HABR model.
To investigate HABR dynamics in a virtual liver graft scenario.

Main Methods:

An electrical analog model was created, incorporating nonlinear resistors for dynamic HABR effects.
The model was calibrated using established hemodynamic data.
Simulations included virtual portal vein occlusion (50% and 100%) and a virtual right-lobe liver graft scenario.

Main Results:

Simulations indicated that increased arterial flow cannot fully compensate for portal perfusion loss during occlusion.
The model successfully reproduced conditions of portal venous hyperperfusion and hepatic arterial hypoperfusion in a virtual graft.
Results align with existing clinical and animal study findings on HABR.

Conclusions:

The simplified electrical analog model effectively captures dynamic HABR effects.
The model provides insights into liver blood flow regulation during portal vein alterations and in transplanted livers.
This computational approach aids in understanding liver hemodynamics and HABR function.