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Updated: May 16, 2026
08:01
Stimulation of Notch Signaling in Mouse Osteoclast Precursors
Published on: February 28, 2017
Notch signaling in pediatric soft tissue sarcomas
Rossella Rota1, Roberta Ciarapica, Lucio Miele
1Department of Oncohematology, Ospedale Pediatrico Bambino Gesù, IRCCS, Piazza Sant'Onofrio 4, Roma, 00165, Italy. rossella.rota@opbg.net
BMC Medicine
|November 20, 2012
Summary
Pediatric soft tissue sarcomas involve abnormal Notch signaling. Targeting this pathway offers new treatment opportunities for these rare childhood cancers, improving patient outcomes.
Area of Science:
- Pediatric Oncology
- Molecular Biology
- Cancer Signaling Pathways
Background:
- Pediatric soft tissue sarcomas are rare childhood cancers often driven by chromosomal translocations.
- Current treatments face challenges with metastatic and aggressive forms, leading to poor survival rates.
- These sarcomas are believed to originate from embryonic mesenchymal progenitor cells with aberrant signaling.
Purpose of the Study:
- To review recent evidence on the role of Notch signaling in pediatric soft tissue sarcomas.
- To highlight the importance of Notch signaling in tumor cell biology.
- To discuss potential therapeutic strategies targeting Notch signaling.
Main Methods:
- Literature review of recent research on Notch signaling in pediatric soft tissue sarcomas.
- Analysis of the molecular mechanisms underlying Notch pathway dysregulation in these tumors.
- Discussion of preclinical and clinical data related to Notch-targeted therapies.
Main Results:
- Notch signaling pathway dysregulation is implicated in the development and progression of pediatric soft tissue sarcomas.
- Aberrant Notch signaling influences key cellular processes, including proliferation and differentiation.
- Emerging evidence suggests Notch pathway components as potential therapeutic targets.
Conclusions:
- Notch signaling plays a critical role in the biology of pediatric soft tissue sarcomas.
- Targeting the Notch pathway presents a promising avenue for novel therapeutic interventions.
- Further research is needed to optimize Notch-targeted therapies for improved clinical outcomes.
Related Concept Videos
03:14Notch Signaling Pathway
The Notch signaling pathway is a major intracellular signaling pathway that is highly conserved over a broad spectrum of metazoan species. It stands unique from other intracellular signaling mechanisms in animals because notch protein itself acts as the receptor as well as the primary signaling molecule.
The Notch gene came into the limelight in 1914 after the discovery that its mutation in Drosophila melanogaster leads to a serrated (or "notched") wing margin phenotype. It was not until 1985...
The Notch gene came into the limelight in 1914 after the discovery that its mutation in Drosophila melanogaster leads to a serrated (or "notched") wing margin phenotype. It was not until 1985...
03:14Notch Signaling Pathway
The Notch signaling pathway is a major intracellular signaling pathway that is highly conserved over a broad spectrum of metazoan species. It stands unique from other intracellular signaling mechanisms in animals because notch protein itself acts as the receptor as well as the primary signaling molecule.
The Notch gene came into the limelight in 1914 after the discovery that its mutation in Drosophila melanogaster leads to a serrated (or "notched") wing margin phenotype. It was not until 1985...
The Notch gene came into the limelight in 1914 after the discovery that its mutation in Drosophila melanogaster leads to a serrated (or "notched") wing margin phenotype. It was not until 1985...
01:12Role Of Notch Signalling In Intestinal Stem Cell Renewal
Notch signaling was first discovered in Drosophila melanogaster, where it is involved in cell lineage differentiation. Notch signaling regulates the maintenance and differentiation of intestinal stem cells or ISCs by controlling the expression of atonal homolog 1 or Atoh1. Atoh1 directs cells to differentiate into secretory cells.
Direct cell-to-cell contact is needed for the activation of Notch signaling. The signal is initiated when a notch ligand binds to a receptor on an adjacent cell, also...
Direct cell-to-cell contact is needed for the activation of Notch signaling. The signal is initiated when a notch ligand binds to a receptor on an adjacent cell, also...
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03:03mTOR Signaling and Cancer Progression
The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
The mTOR pathway or the...
The mTOR pathway or the...
02:23Abnormal Proliferation
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