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Related Experiment Video

Updated: May 16, 2026

Milk Collection in the Rat Using Capillary Tubes and Estimation of Milk Fat Content by Creamatocrit
07:38

Milk Collection in the Rat Using Capillary Tubes and Estimation of Milk Fat Content by Creamatocrit

Published on: December 16, 2015

Cow's milk proteins in human milk.

A Coscia1, S Orrù, P Di Nicola

  • 1Neonatal Unit, University of Turin, Italy.

Journal of Biological Regulators and Homeostatic Agents
|November 20, 2012
PubMed
Summary

Cow's milk allergen alpha-1 casein is present in human colostrum. Further research is needed to determine its role in infant sensitization or tolerance to cow's milk proteins (CMPs).

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Last Updated: May 16, 2026

Milk Collection in the Rat Using Capillary Tubes and Estimation of Milk Fat Content by Creamatocrit
07:38

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Published on: December 16, 2015

An Efficient Single-Person Technique for Milk Sampling from Laboratory Mice
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Published on: March 28, 2025

Area of Science:

  • Allergy and Immunology
  • Proteomics
  • Human Lactation

Background:

  • Cow's milk proteins (CMPs) are common food allergens, with specific whey proteins and caseins identified as allergens.
  • The presence and potential impact of cow's milk allergens in human colostrum require further investigation.

Purpose of the Study:

  • To investigate cow's milk allergens in human colostrum from mothers of term and preterm newborns using proteomics.
  • To identify previously undetected allergens and assess their potential role in infant sensitization during lactation.

Main Methods:

  • Proteomics techniques were employed for direct protein identification in human colostrum samples.
  • Colostrum samples were collected from 62 mothers of term newborns and 11 mothers of preterm newborns.

Main Results:

  • Intact bovine alpha-S1-casein was detected in the colostrum of both term and preterm mothers.
  • Beta-lactoglobulin, another known cow's milk allergen, was not detected in any of the analyzed colostrum samples.

Conclusions:

  • Bovine alpha-1 casein, a major cow's milk allergen, is secreted into human milk.
  • Further research is necessary to elucidate the role of alpha-1 casein in cow's milk sensitization or tolerance in exclusively breastfed infants.