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Photosensitivity disorders in children: part II
Rattanavalai Chantorn1, Henry W Lim, Tor A Shwayder
1Department of Pediatrics, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.
Journal of the American Academy of Dermatology
|November 20, 2012
Summary
Pediatric photosensitivity disorders, including inherited conditions, require early diagnosis and management. Prompt recognition of these photodermatoses and sun protection are crucial for preventing long-term complications.
Area of Science:
- Pediatric Dermatology
- Genetics
- Photobiology
Background:
- Photosensitivity disorders in children are diverse, with some inherited conditions presenting early.
- Extracutaneous associations can be key diagnostic clues for pediatric photodermatoses.
Purpose of the Study:
- To review hereditary photodermatoses in children.
- To discuss the diagnosis and management of photoaggravated dermatoses.
- To emphasize the importance of sun protection and early diagnosis.
Main Methods:
- Review of hereditary photodermatoses.
- Focus on defects in DNA repair pathways (nucleotide excision repair, double strand break repair).
- Discussion of biochemical abnormalities and photoaggravated dermatoses.
Main Results:
- Hereditary photodermatoses result from genetic defects in DNA repair or biochemical pathways.
- Photoaggravated dermatoses are also addressed.
- Sun protection is universally recommended.
Conclusions:
- Early recognition and diagnosis of pediatric photosensitivity are essential.
- Prompt management minimizes long-term complications from inadequate photoprotection.
- Understanding underlying genetic and biochemical factors aids diagnosis.
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