Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Factor VII activation and menopausal status.

P Y Scarabin1, C Bonithon-Kopp, L Bara

  • 1INSERM, U 258, Hôpital Broussais, Paris, France.

Thrombosis Research
|January 15, 1990
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Social deprivation and stroke severity on admission: a French cohort study in Burgundy and the West Indies - Guyana region.

European journal of neurology·2017
Same author

The lupus impact tracker is responsive to changes in clinical activity measured by the systemic lupus erythematosus responder index.

Lupus·2016
Same author

Annual diagnosis rate of superficial vein thrombosis of the lower limbs: the STEPH community-based study.

Journal of thrombosis and haemostasis : JTH·2014
Same author

Statement of severe trauma management in France; teachings of the FIRST study.

Annales francaises d'anesthesie et de reanimation·2013
Same author

Natural history of patients developing thrombocytopenia while receiving anticoagulant therapy for venous thromboembolism.

International angiology : a journal of the International Union of Angiology·2012
Same author

National estimate of multiple sclerosis incidence in France (2001-2007).

Multiple sclerosis (Houndmills, Basingstoke, England)·2012
Same journal

Apoptotic versus procoagulant platelets: similar "necrotic" phenotype and procoagulant activity in vitro, but distinct adhesive protein composition.

Thrombosis research·2026
Same journal

Heatstroke-induced coagulopathy: A scoping review of therapeutic strategies and outcome reporting.

Thrombosis research·2026
Same journal

Mapping thrombus habitat: Non-contrast MRI radiomics and pixel-tile histomics approach to track venous thrombosis evolution in mice.

Thrombosis research·2026
Same journal

A study protocol for a randomised controlled trial evaluating the safety and efficiency of the YEARS algorithm versus computed tomography pulmonary angiography only for suspected acute pulmonary embolism in patients with cancer: the Hydra Study.

Thrombosis research·2026
Same journal

Associating the phenotypic expression of platelets with disease type through image-based single-cell profiling.

Thrombosis research·2026
Same journal

The mechanisms of contractile dysfunction following chronic limited platelet activation in (pro)thrombotic conditions.

Thrombosis research·2026
See all related articles

Postmenopausal women have higher coronary heart disease (CHD) risk, partly due to increased factor VII activation. This study found higher factor VII levels and activity in postmenopausal women, suggesting a link to menopause and increased CHD risk.

Area of Science:

  • Cardiovascular Health
  • Endocrinology
  • Hematology

Background:

  • Coronary heart disease (CHD) incidence is elevated in postmenopausal women compared to premenopausal women.
  • Conventional CHD risk factors do not fully explain this disparity.
  • Factor VII activation is implicated in CHD pathogenesis.

Purpose of the Study:

  • To investigate menopause-related changes in factor VII activation.
  • To assess the relationship between menopause and factor VII coagulant activity (FVIIc) and antigen (FVIIag) levels.
  • To explore the impact of different menopause types on factor VII activation.

Main Methods:

  • Studied 228 healthy women aged 45-54 years.
  • Measured factor VII clotting assay (FVIIc) and factor VII antigen assay (FVIIag).

Related Experiment Videos

  • Analyzed FVIIc/FVIIag ratios in relation to menopausal status.

    • Main Results:

    • Both FVIIc and FVIIag levels were significantly higher in postmenopausal women.
    • The FVIIc/FVIIag ratio was positively associated with menopause.
    • Women who underwent bilateral oophorectomy exhibited the highest FVIIc and FVIIc/FVIIag ratios.

    Conclusions:

    • Raised factor VII coagulant activity in postmenopausal women may contribute to increased CHD risk.
    • Menopause, particularly oophorectomy, is associated with increased factor VII activation.
    • Factor VII activation is a potential non-conventional risk factor for CHD in postmenopausal women.