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Plasmodium protein export at higher PEXEL resolution
1Howard Hughes Medical Institute, Departments of Medicine and Molecular Microbiology, Washington University School of Medicine, St. Louis, MO 63110-1093, USA. goldberg@borcim.wustl.edu
Abstract:
Intraerythrocytic malaria parasites send hundreds of effector proteins into the host cell. Diverse modes of export have been proposed for different proteins. In this issue, Grüring et al. (2012) present findings that bring the models together.
Insights
Malaria parasites export effector proteins into host cells through various mechanisms. Grüring et al. (2012) present new findings that unify these proposed models for protein export.
Area of Science:
- Malariology
- Cellular Biology
- Molecular Parasitology
Background:
- Intraerythrocytic malaria parasites secrete numerous effector proteins into the host erythrocyte.
- The precise mechanisms of protein export from the parasite to the host cell are diverse and not fully understood.
