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Fibrinolytic system in preeclampsia
M B Pinheiro1, K B Gomes, L M S Dusse
1Department of Clinical and Toxicological Analysis, Faculty of Pharmacy/Universidade Federal de Minas Gerais, Brazil.
Clinica Chimica Acta; International Journal of Clinical Chemistry
|November 20, 2012
Summary
Preeclampsia involves a hypercoagulable state, with coagulation activation preceding symptoms. This review explores the fibrinolytic system
Area of Science:
- Obstetrics and Gynecology
- Hematology
- Pathophysiology
Background:
- Preeclampsia (PE) is a pregnancy disorder marked by hypertension and proteinuria.
- Endothelial dysfunction is a suspected key factor in PE pathogenesis.
- Pregnancy normally involves a hypercoagulable state, but PE exacerbates this.
Purpose of the Study:
- To review the role of the fibrinolytic system in preeclampsia.
- To discuss the implications of fibrinolysis in PE pathogenesis.
Main Methods:
- Literature review of studies on coagulation and fibrinolysis in preeclampsia.
- Analysis of existing data on fibrin deposition and regulatory mechanisms.
Main Results:
- Coagulation activation in PE is pronounced and can precede clinical symptoms.
- Fibrin deposition is a common finding in PE, particularly in the kidneys.
- The interplay between coagulation and fibrinolysis in PE is complex and not fully understood.
Conclusions:
- The fibrinolytic system's specific role in preeclampsia requires further clarification.
- Understanding fibrinolysis may offer insights into PE pathogenesis and potential interventions.
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