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Upper Respiratory Drugs: Antitussives, Expectorants, and Mucolytics01:23

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Respiratory symptoms, such as congestion and cough, commonly accompany respiratory tract conditions. Various medications, such as antitussives, expectorants, and mucolytics, play crucial roles in providing relief.
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Related Experiment Video

Updated: May 16, 2026

Methods for Detecting Cough and Airway Inflammation in Mice
04:33

Methods for Detecting Cough and Airway Inflammation in Mice

Published on: August 2, 2024

Novel antitussive strategies.

Jaymin B Morjaria1, Rebecca S Dickinson, Alyn H Morice

  • 1Division of Cardiovascular and Respiratory Studies, Hull York Medical School, University of Hull, Castle Hill Hospital, Cottingham HU16 5JQ, UK. Jaymin.morjaria@hey.nhs.uk

Drug Discovery Today
|November 20, 2012
PubMed
Summary

Effective treatments for acute and chronic cough are lacking. This review explores current antitussive therapies and emerging compounds targeting newly discovered cough pathways.

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Area of Science:

  • Pharmacology
  • Respiratory Medicine
  • Drug Discovery

Background:

  • Cough is a prevalent symptom with limited effective pharmaceutical treatments.
  • Current antitussive pharmacotherapy is largely insufficient for managing acute and chronic cough.
  • Understanding tussive pathways is crucial for developing novel treatments.

Purpose of the Study:

  • To review the existing arsenal of antitussive medications.
  • To provide an update on novel strategies and compounds currently under development for cough suppression.
  • To highlight advancements in targeting newly identified tussive pathways.

Main Methods:

  • Literature review of current antitussive pharmacotherapy.
  • Survey of ongoing research and development in novel antitussive agents.
  • Analysis of emerging compounds targeting specific tussive pathways.

Main Results:

  • The current antitussive armamentarium is limited in efficacy.
  • Several novel strategies and compounds targeting tussive pathways are in development.
  • New therapeutic targets for cough suppression are being identified.

Conclusions:

  • There is a significant unmet need for effective cough pharmacotherapy.
  • Emerging research into tussive pathways offers promising avenues for novel antitussive drug development.
  • Further investigation into novel compounds is warranted to address limitations in current treatments.