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Updated: May 16, 2026
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Induction of Right Ventricular Failure by Pulmonary Artery Constriction and Evaluation of Right Ventricular Function in Mice
Published on: May 13, 2019
Contribution of right ventricular dysfunction to heart failure mortality: a meta-analysis
Ignacio Iglesias-Garriz1, Cristina Olalla-Gómez, Carmen Garrote
1Department of Cardiology, Hospital of the University of León, León, Spain.
Reviews in Cardiovascular Medicine
|November 20, 2012
Summary
Right ventricular systolic dysfunction (RVSD) is linked to worse outcomes in heart failure patients. This meta-analysis confirms RVSD is associated with increased mortality and hospital admissions for heart failure.
Area of Science:
- Cardiology
- Internal Medicine
Background:
- Right ventricular systolic dysfunction (RVSD) is a known factor influencing prognosis in heart failure (HF).
- Previous studies on RVSD and outcomes in left ventricular dysfunction (LVD) have limitations in size, inclusion criteria, and methodology.
- Definitive conclusions regarding the prognostic impact of RVSD in LVD patients remain elusive.
Purpose of the Study:
- To investigate the association between RVSD and clinical outcomes in patients with LVD.
- To synthesize evidence from existing studies through a meta-analysis.
Main Methods:
- A meta-analysis was conducted including eleven studies comprising 4732 patients.
- The prevalence of RVSD was assessed across the included studies.
- Outcomes analyzed included overall mortality and hospital admission for HF.
Main Results:
- RVSD was present in 47.2% of the patients (2234 out of 4732).
- A significant association was found between RVSD and increased overall mortality.
- RVSD was also significantly associated with hospital admission for HF.
- Significant heterogeneity and publication bias were noted, requiring cautious interpretation.
Conclusions:
- RVSD is a significant predictor of adverse outcomes, including mortality and HF readmission, in patients with LVD.
- The findings highlight the prognostic importance of assessing right ventricular function in this patient population.
- Awareness of study heterogeneity and publication bias is crucial when interpreting these results.
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