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Galectin-3 regulates p21 stability in human prostate cancer cells

Y Wang1, V Balan, D Kho

  • 1Department of Oncology, Tumor Progression and Metastasis, Karmanos Cancer Institute, School of Medicine, Wayne State University, Detroit, MI, USA.

Oncogene
|November 20, 2012
PubMed
Summary

Galectin-3 (Gal-3) protein levels correlate with p21 expression in prostate cancer. Modulating p21 reverses Gal-3’s effects on cell growth and apoptosis, revealing Gal-3 as a novel p21 stabilizer.

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