CE-MS for metabolomics: developments and applications in the period 2010-2012

Area of Science:

• Analytical Chemistry
• Biochemistry
• Metabolomics

Background:

• Capillary Electrophoresis-Mass Spectrometry (CE-MS) is crucial for analyzing polar and charged metabolites.
• Previous reviews covered 2000-2010, necessitating an update on recent advancements.

Purpose of the Study:

• To provide an updated review of CE-MS developments in metabolomics.
• To cover literature published between July 2010 and June 2012.
• To highlight technological advancements and applications.

Main Methods:

• Review of scientific literature from July 2010 to June 2012.
• Focus on technological developments, particularly novel interfacing techniques for CE-MS coupling.
• Compilation of recent CE-MS-based metabolomics studies in a table.

Main Results:

• Discussion of emerging technological developments in CE-MS for metabolomics.
• Illustrative examples of CE-MS applications in biomedical, clinical, microbial, plant, environmental, and food metabolomics.
• Comprehensive overview of targeted and non-targeted CE-MS metabolomics studies.

Conclusions:

• CE-MS continues to be a powerful tool for comprehensive metabolomic profiling.
• Recent advancements enhance its applicability across diverse fields.
• The review provides valuable insights into sample handling, capillary coatings, and MS detection modes.