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Updated: May 16, 2026

The Mouse Stroke Unit Protocol with Standardized Neurological Scoring for Translational Mouse Stroke Studies
Published on: February 7, 2025
Updating on Italian stroke units: the "CCM study"
D Guidetti1, M Spallazzi, D Toni
1Department of Neurology, G. da Saliceto Hospital, Via Cantone del Cristo, 29100 Piacenza, Italy. d.guidetti@ausl.pc.it
Stroke units (SUs) improve acute stroke care, but implementation in Italy is uneven. This survey reveals significant regional disparities, particularly in Southern Italy, limiting access to timely thrombolytic treatment.
Area of Science:
- Neurology
- Public Health
- Healthcare Management
Background:
- Stroke units (SUs) are proven effective and cost-efficient for acute stroke care.
- Current implementation of SUs in Italy falls short of expectations, indicating a need for assessment and updates.
Purpose of the Study:
- To assess the current status of in-hospital stroke care across Italian regions.
- To identify the level of stroke unit implementation and adherence to quality indicators.
- To evaluate access to timely thrombolytic therapy.
Main Methods:
- A survey using a semi-structured questionnaire based on 18 stroke care quality indicators.
- Data collected from Italian centers participating in the SITS-MOST study and others identified by experts.
- Statistical analysis included descriptive statistics and logistic regression.
Main Results:
- 153 centers responded, with 137 meeting the definition of a Stroke Unit (SU).
- Most centers (84%) admit 100-500 stroke patients annually. Only 19% treat over 30% of patients within 3 hours of symptom onset.
- Significant territorial heterogeneity observed: 67% of SUs are in Northern Italy, 22% in Central, and only 11% in Southern Italy.
- Thrombolysis rates varied based on on-call doctor availability, with 24-hour doctor presence correlating with higher treatment numbers.
- Despite an overall rise in SUs and thrombolysis, access remains limited in many areas, especially in the South.
Conclusions:
- While the diffusion of SUs and thrombolytic therapy has increased in Italy, significant regional disparities persist.
- Healthcare legislation requirements are unmet in several large areas, particularly in Southern Italy, restricting access to dedicated SUs and timely treatment.
- Further efforts are needed to ensure equitable access to high-quality stroke care throughout Italy.
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