Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Video

Updated: May 16, 2026

Evaluation of Motor Impairment in C. elegans Models of Amyotrophic Lateral Sclerosis

Evaluation of Motor Impairment in C. elegans Models of Amyotrophic Lateral Sclerosis

Published on: September 2, 2021

Trail Making Test error analysis in classic motor neuron disease.

Foteini Christidi¹, Evangelia Kararizou, Nikolaos I Triantafyllou

¹Neuropsychological Lab, A' Department of Neurology, Eginition Hospital, Medical School, National and Kapodistrian University, 72-74 Vas. Sofias Avenue, 115 28, Athens, Greece. christidi.f.a@gmail.com

Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology

|November 20, 2012

Summary

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Advances in Neurological Diseases: Pathogenesis, Diagnosis and Therapeutic Strategies.

Biomedicines·2026

Same author

Explainable Machine Learning Reveals Time-Dependent Cognitive Risk in Minor Neurocognitive Disorder: Implications for Health Promotion and Early Risk Stratification.

Biomedicines·2026

Same author

Person-First or Disease-First? Language Choices in Cancer Communication.

Nursing reports (Pavia, Italy)·2026

Same author

Clinical, Cognitive and Demographic Determinants of Work Participation in Multiple Sclerosis: A Multicenter Cross-Sectional Study.

Medicina (Kaunas, Lithuania)·2026

Same author

The Driving Profile of Individuals with Schizophrenia: Cognitive Characteristics, Pharmacological Treatment and Driving Competence-A Scoping Review.

Neurology international·2026

Same author

Clinical Significance of Microembolic Signal Detection in Acute Ischemic Stroke: Insights Into Ongoing Cerebral Embolization and Occult Etiologies.

European journal of neurology·2026

Neuropsychological assessment using the Quantified Process Approach (QPA) revealed higher error rates on the Trail Making Test Part B in classic motor neuron disease (cMND) patients. Error analysis offers valuable insights beyond completion time for cMND cognitive evaluation.

Area of Science:

Neuropsychology
Neurology

Background:

Classic motor neuron disease (cMND) often involves cognitive flexibility deficits.
Non-traditional scoring in neuropsychological assessments, like the Quantified Process Approach (QPA), enables detailed pattern analysis of test performance.

Purpose of the Study:

To investigate error rates on the Trail Making Test Part B (TMT-B) in patients with cMND using the QPA.
To compare TMT-B error patterns between cMND patients and healthy controls.

Main Methods:

The Quantified Process Approach (QPA) was applied to analyze error rates on the Trail Making Test (TMT) Part B.
Twenty-six non-demented patients with cMND and 26 matched healthy controls participated.

Main Results:

cMND patients demonstrated significantly higher total error rates on the TMT-B compared to controls.

More Related Videos

Clinical Testing and Spinal Cord Removal in a Mouse Model for Amyotrophic Lateral Sclerosis (ALS)

Clinical Testing and Spinal Cord Removal in a Mouse Model for Amyotrophic Lateral Sclerosis (ALS)

Published on: March 17, 2012

Utility of Dissociated Intrinsic Hand Muscle Atrophy in the Diagnosis of Amyotrophic Lateral Sclerosis

Utility of Dissociated Intrinsic Hand Muscle Atrophy in the Diagnosis of Amyotrophic Lateral Sclerosis

Published on: March 4, 2014

Related Experiment Videos

Last Updated: May 16, 2026

Evaluation of Motor Impairment in C. elegans Models of Amyotrophic Lateral Sclerosis

Evaluation of Motor Impairment in C. elegans Models of Amyotrophic Lateral Sclerosis

Published on: September 2, 2021

Clinical Testing and Spinal Cord Removal in a Mouse Model for Amyotrophic Lateral Sclerosis (ALS)

Clinical Testing and Spinal Cord Removal in a Mouse Model for Amyotrophic Lateral Sclerosis (ALS)

Published on: March 17, 2012

Utility of Dissociated Intrinsic Hand Muscle Atrophy in the Diagnosis of Amyotrophic Lateral Sclerosis

Utility of Dissociated Intrinsic Hand Muscle Atrophy in the Diagnosis of Amyotrophic Lateral Sclerosis

Published on: March 4, 2014

A notable percentage of cMND patients made errors on TMT-B even with normal completion times, significantly more than controls.

No significant correlations were found between TMT errors and other executive function/attention measures.

Conclusions:

Error analysis via QPA enhances the clinical utility of the TMT for cMND assessment.
Incorporating QPA error analysis alongside time-to-completion scores is recommended for neuropsychological evaluations in cMND.