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Updated: May 16, 2026

Microprobe Capillary Electrophoresis Mass Spectrometry for Single-cell Metabolomics in Live Frog (Xenopus laevis) Embryos
Published on: December 22, 2017
Recent advances in the combination of capillary electrophoresis with mass spectrometry: from element to single-cell
1Institute of Analytical Chemistry, Academy of Sciences of the Czech Republic, Brno, Czech Republic. klep@iach.cz
Abstract:
This overview deals with the latest development of electrophoresis in capillaries and microfluidic devices coupled to MS detection. A wide selection of relevant articles covers the literature published from January 2010 till June 2012 as a continuation of the review article on the same topic by Pantuckova et al. [Electrophoresis 2011, 32, 43-51]. Special attention is paid to the new improvements in instrumentation and methodology of three interfacing methods, ESI, matrix-assisted desorption/ionization, and ICP. Representative examples illustrate applications in the proteomics, glycomics, metabolomics, biomarker research, forensics, pharmacology, food analysis and single-cell analysis. The combinations of MS with capillary versions of electrochromatography, ITP, IEF, and micellar electrokinetic chromatography are not included.
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