Related Experiment Video
Updated: May 16, 2026
07:56
Transient Middle Cerebral Artery Occlusion Model of Neonatal Stroke in P10 Rats
Published on: April 21, 2017
Neonatal lupus complicated by hemorrhagic stroke.
1Department of Physical Medicine and Rehabilitation, Chang Gung Memorial Hospital, College of Medicine, Chang Gung University, Taoyuan, Taiwan.
Lupus
|November 20, 2012
Summary
Neonatal lupus, an autoimmune condition, can affect the fetal central nervous system. This case highlights a rare instance of neonatal lupus with hemorrhagic stroke and long-term neurological deficits.
Area of Science:
- Immunology
- Neurology
- Pediatrics
Background:
- Neonatal lupus is an autoimmune condition caused by maternal autoantibodies crossing the placenta.
- Central nervous system (CNS) involvement is rarely reported in neonatal lupus, with typically favorable neurological outcomes.
Observation:
- This report details a preterm infant diagnosed with neonatal lupus.
- The infant presented with thrombocytopenia and a concurrent perinatal hemorrhagic stroke.
Findings:
- The infant developed spastic quadriplegia and significant developmental delays post-stroke.
- This represents the first documented case of neonatal lupus associated with perinatal hemorrhagic stroke.
Implications:
- Clinicians should consider regular CNS evaluations in infants diagnosed with neonatal lupus.
- This case underscores the potential for severe neurological complications in neonatal lupus, necessitating vigilant monitoring.
More Related Videos
Related Concept Videos
01:29Hemorrhagic Stroke ll: Pathophysiology
A hemorrhagic stroke develops when a cerebral blood vessel ruptures, allowing blood to escape into the surrounding brain tissue, as in intracerebral hemorrhage (ICH), or into the subarachnoid space, as in subarachnoid hemorrhage (SAH). Because the skull is a rigid compartment, the sudden presence of extravascular blood rapidly increases intracranial pressure and compresses adjacent neural structures, leading to immediate tissue injury and impaired cerebral perfusion.Mass Effect and Primary...
01:17Hemorrhagic Stroke l: Introduction
A hemorrhagic stroke is an acute neurological event that occurs when a weakened cerebral blood vessel ruptures, allowing blood to accumulate within or around the brain. The sudden release of blood forms a focal hematoma that increases intracranial pressure, displaces neural tissue, and can obstruct cerebrospinal fluid pathways. These effects may be compounded by intraventricular extension of the hemorrhage, cerebral edema, or compression of adjacent structures, all of which contribute to...
01:15Ischemic Stroke ll: Pathophysiology
An ischemic stroke occurs when a cerebral blood vessel becomes obstructed, most often by a thrombus or embolus, interrupting the delivery of oxygen and glucose to brain tissue. Because neurons rely on continuous aerobic metabolism, energy failure begins within minutes of reduced perfusion. The region receiving the least blood flow becomes the infarct core, an area of irreversible cellular death. Surrounding this core lies the penumbra, a zone of hypoperfused but still viable tissue that is...