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Related Concept Videos

Peripheral Arterial Disease II: Clinical Manifestations and Diagnostic Evaluation01:21

Peripheral Arterial Disease II: Clinical Manifestations and Diagnostic Evaluation

Clinical manifestationsPeripheral Arterial Disease (PAD) manifests through a range of symptoms, from the characteristic intermittent claudication to atypical presentations and severe complications in advanced stages. Intermittent claudication, a hallmark symptom of PAD, presents as exercise-induced muscle pain that typically resolves within minutes of rest. This pain is reproducible and stems from inadequate blood flow, leading to the accumulation of lactic acid produced during anaerobic...
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Peripheral artery disease (PAD) predominantly results from atherosclerosis, which involves the accumulation of fatty deposits, or plaques, within the walls of arteries. This causes them to narrow and harden, significantly reducing blood flow. PAD predominantly affects the legs, particularly the arteries supplying the thighs and calves. In rare cases, it may involve other arteries, including those in the arms.Etiology of PAD:The principal cause of PAD is atherosclerosis, which results from fatty...
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Local anesthetics (LAs) block the sodium channels of nerve trunks, sensory nerve endings, and neuromuscular junctions. Although LAs can block all kinds of nerves, the sensitivity of nerve fibers differs according to nerve types and structures. LAs are known to block myelinated fibers faster than unmyelinated ones. Also, they block pain or sensory neurons at low concentrations without affecting the motor neurons involved in muscle contractions. This helps relieve labor pain without affecting the...

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Updated: May 16, 2026

Screening of Axonal Degeneration in Carpal Tunnel Syndrome Using Ultrasonography and Nerve Conduction Studies
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Serial anthropometry predicts peripheral nerve dysfunction in a community cohort.

Kelly R Ylitalo1, William H Herman, Siobán D Harlow

  • 1Department of Epidemiology, University of Michigan, Ann Arbor, MI 48109, USA. kylitalo@umich.edu

Diabetes/Metabolism Research and Reviews
|November 20, 2012
PubMed
Summary
This summary is machine-generated.

Obesity is a significant risk factor for peripheral nerve dysfunction in women, independent of glucose intolerance. Early differences in body size predict future nerve problems, highlighting obesity as a key modifiable risk factor.

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Area of Science:

  • Endocrinology
  • Neurology
  • Public Health

Background:

  • Obesity is a known risk factor for glucose intolerance.
  • The independent role of obesity in peripheral neuropathy development remains unclear.
  • This study investigates body size trajectories and nerve dysfunction in women.

Purpose of the Study:

  • To assess the impact of body size trajectories on prevalent nerve dysfunction.
  • To determine if obesity independently contributes to peripheral neuropathy.
  • To examine these relationships in community-dwelling women with and without glucose intolerance.

Main Methods:

  • Annual anthropometric measures (weight, height, waist circumference, BMI) collected from 1996-2008.
  • Glucose intolerance defined annually based on medication use, diagnosis, or fasting glucose.
  • Peripheral nerve dysfunction assessed in 2008 via monofilament testing and symptom/sign evaluation.

Main Results:

  • Mean BMI was 32.4 kg/m², with 27.8% of women experiencing nerve dysfunction in 2008.
  • Women who developed nerve dysfunction were significantly larger at baseline, independent of glucose intolerance.
  • Body size differences were maintained over time, not exacerbated.

Conclusions:

  • Peripheral nerve dysfunction is prevalent in community-dwelling women.
  • Differences in anthropometry 12 years prior predicted subsequent nerve dysfunction.
  • Obesity is a significant, potentially modifiable risk factor for peripheral nerve dysfunction.