Related Experiment Video
Updated: May 16, 2026
14:57
Yeast As a Chassis for Developing Functional Assays to Study Human P53
Published on: August 4, 2019
The TP53 website: an integrative resource centre for the TP53 mutation database and TP53 mutant analysis.
Bernard Leroy1, Jean Louis Fournier, Chikashi Ishioka
1Université Pierre et Marie Curie-Paris6, 75005 Paris, France.
Nucleic Acids Research
|November 20, 2012
Summary
A new TP53 mutation database and analysis tools are now available. This resource aids research into TP53 gene dysfunction, crucial for understanding and treating human cancers.
Area of Science:
- Oncology
- Genetics
- Bioinformatics
Background:
- TP53 gene dysfunction is prevalent in most human cancers.
- TP53 mutations are valuable biomarkers for clinical studies and exposome analysis.
- Thousands of reports detail TP53 gene status in over 10,000 tumors.
Purpose of the Study:
- To develop a novel resource center for TP53 mutations and mutants.
- To provide curated data and analytical tools for TP53 mutation research.
- To enhance the understanding of TP53 mutant properties and functions.
Main Methods:
- Development of the UMD TP53 mutation database, updated since 1990.
- Creation of TP53MULTLoad, a manually curated database of 2549 missense TP53 mutants.
- Implementation of multi-platform analytical software and downloadable tools for TP53 mutation analysis.
Main Results:
- A comprehensive, curated database of TP53 mutations is now accessible.
- TP53MULTLoad contains over 100,000 entries across 39 activity fields for TP53 mutants.
- The resource includes data on transactivation, apoptosis, growth arrest, and gain-of-function activities.
Conclusions:
- The developed resource center offers valuable tools for TP53 mutation research.
- Enhanced analysis of TP53 mutants can advance cancer biomarker discovery and therapeutic strategies.
- The user-friendly interface facilitates browsing and analysis of TP53 mutation data.
More Related Videos
Related Concept Videos
01:12Loss of Tumor Suppressor Gene Functions
Tumor suppressor genes are normal genes that can slow down cell division, repair DNA mistakes, or program the cells for apoptosis in case of irreparable damage. Hence, they play an essential role in preventing the proliferation of damaged cells.
When the tumor suppressor genes develop mutations or are lost, cells start growing out of control, leading to cancer. However, a single functional copy of the tumor suppressor gene is enough for the cells to maintain their normal functions and cell...
When the tumor suppressor genes develop mutations or are lost, cells start growing out of control, leading to cancer. However, a single functional copy of the tumor suppressor gene is enough for the cells to maintain their normal functions and cell...
01:12Loss of Tumor Suppressor Gene Functions
Tumor suppressor genes are normal genes that can slow down cell division, repair DNA mistakes, or program the cells for apoptosis in case of irreparable damage. Hence, they play an essential role in preventing the proliferation of damaged cells.
When the tumor suppressor genes develop mutations or are lost, cells start growing out of control, leading to cancer. However, a single functional copy of the tumor suppressor gene is enough for the cells to maintain their normal functions and cell...
When the tumor suppressor genes develop mutations or are lost, cells start growing out of control, leading to cancer. However, a single functional copy of the tumor suppressor gene is enough for the cells to maintain their normal functions and cell...
01:05Cancer-Critical Genes II: Tumor Suppressor Genes
Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
01:05Cancer-Critical Genes II: Tumor Suppressor Genes
Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
02:23Abnormal Proliferation
Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the daughter...
02:07Tumor Progression
Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...