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Related Experiment Video

Updated: May 16, 2026

In Vivo Imaging of Dauer-specific Neuronal Remodeling in C. elegans

In Vivo Imaging of Dauer-specific Neuronal Remodeling in C. elegans

Published on: September 4, 2014

Complex small-molecule architectures regulate phenotypic plasticity in a nematode.

Neelanjan Bose¹, Akira Ogawa, Stephan H von Reuss

¹Boyce Thompson Institute and Department of Chemistry, Cornell University, Ithaca, NY, USA.

Angewandte Chemie (International Ed. in English)

|November 20, 2012

Summary

The nematode Pristionchus pacificus creates unique small molecules from basic metabolic components. These molecules regulate worm development and phenotypic changes, showcasing a novel way to generate biological diversity.

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Last Updated: May 16, 2026

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Quantitative Approaches for Studying Cellular Structures and Organelle Morphology in Caenorhabditis elegans

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Published on: July 30, 2018

Area of Science:

Biochemistry
Molecular Biology
Developmental Biology

Background:

Nematodes exhibit complex developmental processes.
Small molecules play crucial roles in biological signaling and development.
Metabolic pathways provide building blocks for diverse biomolecules.

Purpose of the Study:

To investigate the unique small molecules synthesized by the nematode Pristionchus pacificus.
To understand the role of these molecules in controlling phenotypic plasticity and dauer development.
To explore the mechanisms of structural diversity generation in metazoans.

Main Methods:

Analysis of primary metabolism in Pristionchus pacificus.
Identification and characterization of novel small molecules, including xylopyranose-based nucleosides.
Investigation of the signaling functions of these compounds in nematode development.

Main Results:

Pristionchus pacificus synthesizes elaborate small molecules from modified metabolic building blocks.
An unusual xylopyranose-based nucleoside was identified as a key component.
These compounds were found to control adult phenotypic plasticity and dauer development.

Conclusions:

Pristionchus pacificus employs a unique chemical strategy for development and adaptation.
The identified small molecules represent a novel class of signaling compounds in metazoans.
This study provides insights into the modular generation of structural diversity through metabolic modification.