Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Phases of Wound Repair

Phases of Wound Repair

Following injury, the integrity of the injured tissues must be reestablished. For example, in skin tissue, wound repair involves coordination among resident skin cells, blood mononuclear cells, extracellular matrix, growth factors, and cytokines to complete the healing cascade.
Formation of Blood Clot
In case of deep injuries, trauma to blood vessels results in blood loss. In the meantime, phospholipids released from the ruptured endothelial cellular membrane are converted into arachidonic...

Inflammatory Response II: Inflammatory Exudate and Tissue Repair

Inflammatory Response II: Inflammatory Exudate and Tissue Repair

The immune system's inflammatory response destroys the invading pathogen, permitting the tissue to heal. The changes during the cellular and vascular stages allow exudate formation at the site of inflammation. The inflammatory exudate released from the wound has high protein content and a specific gravity above 1.020.
The typical wound exudate is odorless, transparent, straw-colored, thin, and watery. Exudate, however, can differ depending on the state of wound healing. Likewise, the exudate's...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Unmasking nasal basal cell carcinoma: Strategies for defect coverage.

The Medical journal of Malaysia·2025

Same author

Chimeric Free Fibula Osteocutaneus Flap and Massive Allograft for Refractory Post-traumatic Osteomyelitis Femur Defect: A Case Report.

Malaysian orthopaedic journal·2025

Same author

The Outcomes of Delayed Revascularization in Lower Extremity Vascular Injury: A Retrospective Cohort Study.

Malaysian orthopaedic journal·2025

Same author

Estimation of Total Body Surface Area Burned: A Comparison Between Burn Unit and Referring Facilities.

Annals of burns and fire disasters·2024

Same author

Patency of permanent vascular access creation in paediatric patients with end stage renal disease.

The Medical journal of Malaysia·2021

Same author

Superallowed α Decay to Doubly Magic ^{100}Sn.

Physical review letters·2018

Search research articles

Related Experiment Video

Updated: May 16, 2026

Development of a Benchtop Model for Evaluating the Compatibility of Wound Dressing Materials with Negative Pressure Wound Therapy Systems

Development of a Benchtop Model for Evaluating the Compatibility of Wound Dressing Materials with Negative Pressure Wound Therapy Systems

Published on: May 2, 2025

Wound bed preparation from a clinical perspective.

A S Halim¹, T L Khoo, A Z Mat Saad

¹Department of Reconstructive Sciences, School of Medical Sciences, Universiti Sains Malaysia, 16150 Kubang Kerian, Kelantan, Malaysia.

Indian Journal of Plastic Surgery : Official Publication of the Association of Plastic Surgeons of India

|November 20, 2012

Summary

Wound bed preparation, using the TIME framework (Tissue, Infection/Inflammation, Moisture, Edge), systematically guides wound assessment and management. Advanced wound care now emphasizes a holistic patient approach, integrating various debridement and moisture balance techniques for optimal healing.

Keywords:

Chronic wound negative pressure therapy ulcer wound wound bed

More Related Videos

Application of Lucilia sericata Larvae in Debridement of Pressure Wounds in Outpatient Settings

Application of Lucilia sericata Larvae in Debridement of Pressure Wounds in Outpatient Settings

Published on: December 4, 2021

Swine Model of Biofilm Infection and Invisible Wounds

Swine Model of Biofilm Infection and Invisible Wounds

Published on: June 16, 2023

Related Experiment Videos

Last Updated: May 16, 2026

Development of a Benchtop Model for Evaluating the Compatibility of Wound Dressing Materials with Negative Pressure Wound Therapy Systems

Development of a Benchtop Model for Evaluating the Compatibility of Wound Dressing Materials with Negative Pressure Wound Therapy Systems

Published on: May 2, 2025

Application of Lucilia sericata Larvae in Debridement of Pressure Wounds in Outpatient Settings

Application of Lucilia sericata Larvae in Debridement of Pressure Wounds in Outpatient Settings

Published on: December 4, 2021

Swine Model of Biofilm Infection and Invisible Wounds

Swine Model of Biofilm Infection and Invisible Wounds

Published on: June 16, 2023

Area of Science:

Wound Healing and Tissue Repair
Regenerative Medicine
Clinical Dermatology

Background:

Wound bed preparation (WBP) is a cornerstone of modern wound management, established over two decades.
The TIME acronym (Tissue debridement, Infection/Inflammation control, Moisture balance, Edge of wound) provides a systematic framework for WBP.
Evolving concepts in WBP increasingly emphasize a holistic patient-centered approach beyond the local wound environment.

Purpose of the Study:

To review the principles and clinical management components of wound bed preparation.
To discuss the scientific advancements and clinical perspectives in WBP over the past two decades.
To highlight the integration of advanced wound care principles into contemporary practice.

Main Methods:

Literature review of wound bed preparation concepts and techniques.
Discussion of debridement modalities, including traditional and advanced methods.
Analysis of strategies for managing bacterial balance and achieving optimal wound moisture.

Main Results:

Wound bed preparation, guided by the TIME framework, remains a critical aspect of wound management.
Diverse debridement techniques, from simple to advanced (e.g., enzymatic, surgical), are available for tissue necrosis.
Restoring bacterial balance and achieving a moist wound environment are crucial for healing chronic wounds, with negative pressure wound therapy noted as a significant advancement.

Conclusions:

Current wound bed preparation integrates a comprehensive approach, addressing tissue, infection, moisture, and edge.
Advanced wound care principles, including holistic patient management and innovative therapies, are essential for effective chronic wound treatment.
Continued understanding of the scientific basis of wound healing supports the evolution of clinical wound bed preparation strategies.