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Related Experiment Videos

Perphenazine-induced priapism.

J Chan1, B K Alldredge, L S Baskin

  • 1Division of Clinical Pharmacy, School of Pharmacy, University of California, San Francisco 94143.

DICP : the Annals of Pharmacotherapy
|March 1, 1990
PubMed
Summary
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Perphenazine use can cause prolonged erections (priapism) in men with schizophrenia. Switching to thiothixene resolved the priapism, indicating a potential drug-related side effect.

Area of Science:

  • Psychiatry
  • Pharmacology
  • Urology

Background:

  • Schizophrenia treatment often involves antipsychotic medications.
  • Perphenazine is a typical antipsychotic used for managing schizophrenia.
  • Priapism is a prolonged, painful erection, a potential adverse effect of certain medications.

Observation:

  • A 29-year-old male patient developed recurrent priapism during perphenazine treatment for paranoid schizophrenia.
  • Episodes of priapism lasted over five hours and required medical intervention.
  • Interventions included aspiration of blood from corpora cavernosa and operative shunting.

Findings:

  • Discontinuation of perphenazine led to the resolution of priapism.
  • Subsequent treatment with thiothixene resulted in normal erectile function without recurrence.

Related Experiment Videos

  • This suggests a causal link between perphenazine and priapism in this patient.

    • Implications:

    • Clinicians should be vigilant for priapism as a potential side effect of perphenazine.
    • Alternative antipsychotics, such as thiothixene, may be considered for patients experiencing priapism.
    • Understanding drug-induced priapism is crucial for patient safety and treatment adherence.