Effect of cimetidine on oral digoxin absorption
B Mouser1, D Nykamp, J E Murphy
1Mercer University School of Pharmacy, Department of Pharmacy, Atlanta, GA 30312.
DICP : the Annals of Pharmacotherapy
|March 1, 1990
Summary
Cimetidine does not significantly affect digoxin pharmacokinetics in patients with heart failure. This study found no significant differences in digoxin levels or elimination when combined with cimetidine.
Area of Science:
- Pharmacology
- Clinical Pharmacy
- Cardiology
Background:
- Cimetidine, a histamine H2-receptor antagonist, is widely used for acid-related disorders.
- Cimetidine is known to interact with various medications, potentially affecting drugs with a narrow therapeutic index.
- Previous reports on cimetidine-digoxin interaction are conflicting.
Purpose of the Study:
- To investigate the pharmacokinetic interaction between cimetidine and digoxin in patients with congestive heart failure.
- To determine if cimetidine alters the disposition of chronically administered digoxin.
Main Methods:
- Six hospitalized patients with stable congestive heart failure were enrolled.
- Patients received their standard digoxin maintenance dose.
- Cimetidine was administered after steady-state digoxin concentrations were confirmed.
Main Results:
- Analysis of digoxin serum concentrations showed no significant changes.
- Area under the curve (AUC) for digoxin remained comparable.
- The rate of digoxin elimination was not significantly different when cimetidine was co-administered.
Conclusions:
- Cimetidine does not appear to significantly alter the pharmacokinetic disposition of chronic digoxin therapy in patients with congestive heart failure.
- These findings suggest a lack of clinically significant interaction between cimetidine and digoxin in this patient population.
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