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The VPAC1 receptor: structure and function of a class B GPCR prototype.

A Couvineau1, E Ceraudo, Y-V Tan

  • 1Faculté de Médecine Xavier Bichat, INSERM 773/Centre de Recherche Biomédicale Bichat Beaujon (CRB3), Université Paris 7 Paris Cedex 18, France.

Frontiers in Endocrinology
|November 20, 2012
PubMed
Summary

Vasoactive Intestinal Peptide (VIP) binds to the VPAC1 receptor's N-terminal ectodomain and transmembrane domain. This interaction is crucial for VIP's role in treating neurodegenerative and inflammatory diseases.

Keywords:
GPCRVIPVPAC1inflammationmolecular modelingmutagenesisneuroprotectionphotolabeling

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