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Experimental Melanoma Immunotherapy Model Using Tumor Vaccination with a Hematopoietic Cytokine
Published on: February 24, 2023
Turning the tumor microenvironment into a self vaccine site
1Immunology and Cancer Group; School of Biomedical Sciences; Curtin University; Kent St.; Bentley; Perth, WA Australia ; Western Australian Biomedical Research Institute; Bentley; Perth, WA Australia ; Curtin Health Innovation Research Institute; Bentley; Perth, WA Australia.
Abstract:
We aimed to determine if the tumor microenvironment could be turned into a "self"-vaccine site. We show that provoking a local inflammatory response modulates endothelia to permit the infiltration of innate and adaptive effector cells which collaborate to eradicate the inflamed tumor and other tumor deposits, and provide long-term protection.
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