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Updated: Aug 1, 2026

Transthoracic Echocardiography in Mice
Published on: May 29, 2010
[Doppler echocardiography evaluation of left ventricular function in intra-aortic balloon counterpulsation]
G S Werner1, G Sold, S Andreas
1Abteilung für Kardiologie und Pulmonologie im Zentrum Innere Medizin, Georg-August-Universität Göttingen.
Insights
Intra-aortic balloon counterpulsation (IABP) increases transaortic flow and cardiac output, as shown by Doppler echocardiography. However, IABP does not significantly affect diastolic transmitral flow parameters.
Area of Science:
- Cardiology
- Cardiovascular Physiology
- Medical Imaging
Abstract:
Doppler-echocardiographic measurement of transaortic and mitral flow allows an assessment of systolic and diastolic left ventricular performance. To evaluate the hemodynamic effects of intra-aortic balloon counterpulsation (IABP) 10 patients were examined during IABP after myocardial infarction or cardiothoracic surgery. Doppler echocardiographic transaortic (VAo), early (VE) and late (VA) transmitral flow velocities, transaortic velocity time integral (VTIAo), acceleration and deceleration intervals and rates were obtained. The IABP augmentation was changed from 1:1, 1:2 to 1:4 causing no notable change in invasively measured arterial pressures (p greater than 0.05). With constant heart rate the VE/VA ratio was similar in 1:2 and 1:1 mode (1.44 +/- 0.42 vs 1.47 +/- 0.27; p greater than 0.2), whereas VAo and VTIAo were increased (p less than 0.01). A beat-to-beat analysis during 1:2 mode confirmed an increase in VAo (84.1 +/- 13.5 vs 98.3 +/- 16.5 cm/s; p less than 0.01) and VTIAo after the augmenting balloon inflation, but did not confirm any concomitant effect on diastolic transmitral parameters; acceleration and deceleration intervals were not changed. Thus, Doppler-echocardiography was able to detect an increase in transaortic flow during IABP augmentation by beat-to-beat analysis. The increase in VTIAo indicates an elevated cardiac output. A similar instantaneous effect on the diastolic transmitral flow could not be identified.
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