Related Experiment Video
Updated: May 16, 2026
21:24
Methylated DNA Immunoprecipitation
Published on: January 2, 2009
Interactions between epigenetics and metabolism in cancers.
Jihye Yun1, Jared L Johnson, Christin L Hanigan
1Department of Systems Biology, Harvard Medical School Boston, MA, USA.
Frontiers in Oncology
|November 20, 2012
Summary
Cancer cells exploit epigenetic alterations, including DNA and histone modifications, to control gene expression. These epigenetic changes are influenced by cellular metabolism, highlighting a crucial link between cancer epigenetics and metabolism.
Area of Science:
- Oncology
- Molecular Biology
- Biochemistry
Background:
- Cancer progression involves significant transcriptional and metabolic changes.
- Epigenetic alterations, alongside genetic mutations, play a fundamental role in tumorigenesis.
- Epigenetic modifications, such as post-translational histone and DNA modifications, regulate oncogene and tumor suppressor expression.
Purpose of the Study:
- To provide an overview of cancer epigenetics and metabolism.
- To illustrate the convergence points between cancer epigenetics and metabolism.
Main Methods:
- This review synthesizes current research on cancer epigenetics and metabolism.
- It examines how epigenetic machinery, reliant on metabolites, is influenced by cellular metabolic state.
- Examples of the interplay between epigenetics and metabolism in cancer are presented.
Main Results:
- Epigenetic machinery requires metabolites, making their activity sensitive to cellular metabolic status.
- Cancer cells leverage epigenetic modifications to alter the expression of key cancer-related genes.
- The metabolic state of a cell can directly impact epigenetic regulation.
Conclusions:
- There is a significant convergence between cancer epigenetics and metabolism.
- Understanding this interplay is crucial for developing novel cancer therapies.
- Metabolic interventions may offer new avenues for targeting epigenetic dysregulation in cancer.
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X-chromosome...
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01:46Epigenetic Regulation
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