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A new vaccine against tick-borne encephalitis: initial trial in man including a dose-response study
H L Bock1, U Klockmann, C Jüngst
1Smith Kline Dauelsberg GmbH, Clinical Research, München, FRG.
Vaccine
|February 1, 1990
Abstract:
A new vaccine against tick-borne encephalitis was investigated in 56 healthy volunteers randomized for five different doses of antigen in a comparative group trial. Good tolerability and high immunogenicity were found using three different antibody test systems. The dose response study revealed that there was a strong relationship between the amount of antigen administered and the antibody response over the range of 0.03-3.0 micrograms antigen per dose.