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Updated: May 16, 2026

Evaluation of Host-Pathogen Responses and Vaccine Efficacy in Mice
Published on: February 22, 2019
[Immunocorrection of apoptogenic effect of pertussis preparations with neutrophilokines]
Aim:
Study the possibility of resistance increase of macrophages of experimental animals to apoptogenic effect of pertussis preparations with neutrophilokines.
Materials And Methods:
Apoptosis was evaluated in Coulter flow cytofluorimeter after staining with propidium iodide, as well as by characteristic morphologic changes in cells stained by histological preparations and by DNA fragmentation.
Results:
The studies performed showed that pertussis preparations cause apoptosis of peritoneal macrophages leading to their alteration. Neutrophilokines induced by pertussis preparations were also established to suppress macrophage apoptosis.
Conclusion:
The results of our studies indicate the possibility to use neutrophilokines for immunocorrection of macrophage apoptosis induced by pertussis preparations.
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