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Related Concept Videos

Local Anesthetics: Differential Sensitivity of Nerve Fibers01:24

Local Anesthetics: Differential Sensitivity of Nerve Fibers

Local anesthetics (LAs) block the sodium channels of nerve trunks, sensory nerve endings, and neuromuscular junctions. Although LAs can block all kinds of nerves, the sensitivity of nerve fibers differs according to nerve types and structures. LAs are known to block myelinated fibers faster than unmyelinated ones. Also, they block pain or sensory neurons at low concentrations without affecting the motor neurons involved in muscle contractions. This helps relieve labor pain without affecting the...
Major Somatic Sensory Pathways01:28

Major Somatic Sensory Pathways

Sensory impulses related to touch, pressure, vibration, and proprioception from various body parts, such as the limbs, trunk, neck, and posterior head, travel to the cerebral cortex through the posterior column-medial lemniscus pathway. The pathway’s name derives from the two white-matter tracts that convey the impulses: the spinal cord's posterior column and the brainstem's medial lemniscus. First-order sensory neurons extend their axons into the spinal cord, forming the posterior columns...
Somatic Spinal Reflexes01:22

Somatic Spinal Reflexes

Somatic spinal reflexes are rapid, involuntary muscular responses to external stimuli that involve the somatic musculature and the spinal cord.
One of the most well-known somatic spinal reflexes is the stretch reflex, which is activated by the sudden stretching of a muscle. This reflex involves the activation of specialized sensory receptors called muscle spindles, which are located in the muscle tissue and detect changes in the length and speed of muscle contractions. When a muscle is suddenly...
Somatosensation01:33

Somatosensation

The somatosensory system relays sensory information from the skin, mucous membranes, limbs, and joints. Somatosensation is more familiarly known as the sense of touch. A typical somatosensory pathway includes three types of long neurons: primary, secondary, and tertiary. Primary neurons have cell bodies located near the spinal cord in groups of neurons called dorsal root ganglia. The sensory neurons of ganglia innervate designated areas of skin called dermatomes.
Reticular Dermis01:15

Reticular Dermis

The papillary and reticular dermis are the two layers of the dermis. They are made of connective tissue with fibers of collagen extending from one to the other, making the border between the two somewhat indistinct. The dermal papillae extending into the epidermis belong to the papillary layer, whereas the dense collagen fiber bundles below belong to the reticular layer.
Reticular Layer
Underlying the papillary layer is the much thicker reticular layer, composed of dense, irregular connective...
Papillary Dermis01:11

Papillary Dermis

Dermis
The dermis might be considered the "core" of the integumentary system, as distinct from the epidermis and hypodermis. It contains blood and lymph vessels, nerves, and other structures, such as hair follicles and sweat glands. The dermis is made of two layers of connective tissue that comprise an interconnected mesh of elastin and collagenous fibers, produced by fibroblasts.
Papillary Layer
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Related Experiment Video

Updated: May 16, 2026

Demonstration of Cutaneous Allodynia in Association with Chronic Pelvic Pain
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Published on: June 23, 2009

Two contrasting post-zoster dermatomal phenomena.

Sheikh Javeed Sultan1, Farah Sameem

  • 1Department of Dermatology, SKIMS Medical College, Srinagar, Kashmir, India. sjsultan@gmail.com

Skinmed
|November 21, 2012
PubMed
Summary
This summary is machine-generated.

This study presents two cases: one of psoriasis following herpes zoster and another of ampicillin-induced drug dermatitis. Both conditions presented with distinct skin eruptions, highlighting the importance of accurate diagnosis and treatment.

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Intravital Two-Photon Imaging of Touch Sensory Axon Morphology in Mouse Skin
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Intravital Two-Photon Imaging of Touch Sensory Axon Morphology in Mouse Skin
07:51

Intravital Two-Photon Imaging of Touch Sensory Axon Morphology in Mouse Skin

Published on: December 30, 2025

Area of Science:

  • Dermatology
  • Immunology

Background:

  • Herpes zoster (shingles) can sometimes be followed by other dermatological conditions.
  • Drug reactions, such as ampicillin-induced dermatitis, can mimic other skin conditions.

Observation:

  • A patient developed scaly, pruritic plaques in a dermatomal pattern post-herpes zoster, diagnosed as psoriasis.
  • Another patient presented with fever, arthralgia, and a generalized erythematous dermatitis after ampicillin use, diagnosed as drug-induced dermatitis.

Findings:

  • Histopathology confirmed psoriasis in the first case with a positive Auspitz sign.
  • The second case showed eosinophilia and interface dermatitis, consistent with ampicillin-induced drug dermatitis.

Implications:

  • Dermatomal eruptions post-herpes zoster may indicate underlying psoriasis.
  • Early identification and cessation of offending drugs are crucial for managing drug-induced dermatitis.