Optic disc neovascularization revealing neurosyphilis
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Updated: May 16, 2026

The Rodent Model of Nonarteritic Anterior Ischemic Optic Neuropathy (rNAION)
Published on: November 20, 2016
F Trechot1, T Maalouf, P Kaminsky
1Department of Ophthalmology, CHU-Nancy, France.
Purpose:
To report a case of neurosyphilis revealed by bilateral optic disc neovascularization.
Design:
Case report.
Methods:
A 39-year-old man presented with a 6-month history of progressive visual loss (20/25 RE, 20/1200 LE) and transient headaches. Fundus examination demonstrated a 1+ vitritis, mild macular edema and large optic disc neovascularization in both eyes. Serological tests for syphilis were positive.
Results:
Specific antibiotics and systemic steroids were undertaken and complete regression of disc neovascularization was observed within 6 months.
Conclusion:
Optic disc neovascularization, which is a rare manifestation of chronic uveitis, may lead to the diagnosis of neurosyphilis and be successfully treated by specific antibiotic and steroid therapy.
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