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Cardiac troponin I in congenital heart defects with pressure or volume overload

Anneli Eerola1, Eero O Jokinen, Tanja I Savukoski

  • 1Department of Pediatrics, Tampere University Hospital, Tampere, Finland. anneli.eerola@fi mnet.fi

Scandinavian Cardiovascular Journal : SCJ
|November 21, 2012
PubMed

Insights

Cardiac troponin I (cTnI) release is more common in children with pressure overload congenital heart defects than volume overload. This cardiac biomarker elevation typically resolves after treatment.

Area of Science:

  • Pediatric Cardiology
  • Biomarkers in Congenital Heart Disease

Background:

  • Congenital heart defects (CHDs) can lead to volume or pressure overload.
  • Cardiac troponin I (cTnI) is a marker of myocardial injury.
  • Autoantibodies to cTn may play a role in cardiac conditions.

Purpose of the Study:

  • To determine the prevalence of cTnI and anti-cTn autoantibodies in children with CHDs causing overload.
  • To compare cTnI levels in children with pressure overload versus volume overload CHDs.
  • To assess changes in cTnI after treatment for CHDs.

Main Methods:

  • Study included 78 children with volume overload CHDs, 60 with pressure overload CHDs, and 74 healthy controls.
  • Serum levels of natriuretic peptides, cTnI, and anti-cTn autoantibodies were measured at baseline and 6 months post-treatment.
  • Analysis compared baseline characteristics and outcomes between groups.

Main Results:

  • Baseline cTnI was positive in 1 child (volume overload), 12 children (pressure overload), and 1 control.
  • Children with positive cTnI and pressure overload were younger, had higher natriuretic peptides, and greater pressure gradients.
  • Post-treatment, 63 of 64 children showed negative cTnI levels.

Conclusions:

  • Pressure overload in CHDs is more strongly associated with cTnI release than volume overload.
  • cTnI elevation in these pediatric patients is generally transient and resolves post-intervention.
  • cTnI may serve as a useful biomarker for assessing the impact of pressure overload in CHDs.
Abstract

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