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Selenium and colorectal adenomas risk: a meta-analysis
Yiyi Ou1, Bei Jiang, Xiaoli Wang
1Faculty of Naval Medicine, Second Military Medical University, Shanghai, China.
Nutrition and Cancer
|November 21, 2012
Summary
Higher selenium levels in the blood are linked to a reduced risk of colorectal adenomas. This meta-analysis suggests selenium offers a protective effect against these growths.
Area of Science:
- Biochemistry
- Oncology
- Nutritional Science
Background:
- Selenium is a key component of antioxidant enzymes.
- Previous research suggests a potential role for selenium in preventing colorectal adenomas.
Purpose of the Study:
- To conduct a meta-analysis assessing the association between blood selenium levels and the risk of colorectal adenomas.
- To quantify the relationship using pooled data from multiple studies.
Main Methods:
- Meta-analysis of 7 studies (3 cross-sectional, 3 case-control, 1 nested case-control) published before December 2011.
- Utilized fixed and random-effects models to calculate odds ratios (OR) and 95% confidence intervals (CI).
- Assessed heterogeneity using Cochrane Q-test and I² statistic.
Main Results:
- A significant inverse correlation was found between selenium levels and colorectal adenoma risk.
- The overall odds ratio for the highest to lowest selenium level group was 0.67 (95% CI: 0.55-0.81).
- Moderate heterogeneity was observed among the pooled studies (P = 0.05, I² = 48%).
Conclusions:
- The findings suggest a protective effect of selenium against colorectal adenomas.
- Further research should consider factors like age, gender, smoking, and adenoma characteristics.
