Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Rous Sarcoma Virus (RSV) and Cancer

Rous Sarcoma Virus (RSV) and Cancer

Rous Sarcoma virus or RSV was discovered by F. Peyton Rous in the year 1911 as a filterable transmissible agent that could cause tumors in chickens. He won a Nobel Prize for this discovery in 1966. His experiments clearly demonstrated that some cancers could be caused by infectious agents and led to the discovery of many more cancer-causing viruses in animals as well as humans.
RSV is a retrovirus that contains two copies of a plus-strand RNA genome. Its genome consists of four main open...

Rous Sarcoma Virus (RSV) and Cancer

Rous Sarcoma Virus (RSV) and Cancer

Rous Sarcoma virus or RSV was discovered by F. Peyton Rous in the year 1911 as a filterable transmissible agent that could cause tumors in chickens. He won a Nobel Prize for this discovery in 1966. His experiments clearly demonstrated that some cancers could be caused by infectious agents and led to the discovery of many more cancer-causing viruses in animals as well as humans.
RSV is a retrovirus that contains two copies of a plus-strand RNA genome. Its genome consists of four main open...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Bed occupancy forecast for decision-making during periods of high hospital pressure.

International journal of medical informatics·2026

Same author

Expanding the experimental EuroQol toddler and infant populations (EQ-TIPS) descriptive system: comparing 3-level and 5-level performance for infants and toddlers with chronic conditions.

Journal of patient-reported outcomes·2026

Same author

Estimating worker reentry times following application of two generic spray polyurethane foam formulations according to ASTM Standard Practice D8445-22a.

Journal of occupational and environmental hygiene·2026

Same author

What Endocrinologists Should Know About Iodine: Population Deficiency, Individual Excess and Misinformation in the United Kingdom.

Clinical endocrinology·2026

Same author

Evaluating the current neuro-oncology capacity in Sub-Saharan Africa: A questionnaire-based survey.

Neuro-oncology practice·2026

Same author

A Note on the Magnitude of the Feedback Effect in Environmentally Extended Multi-Region Input-Output Tables.

Journal of industrial ecology·2026

Search research articles

Related Experiment Video

Updated: May 16, 2026

Tumorsphere Derivation and Treatment from Primary Tumor Cells Isolated from Mouse Rhabdomyosarcomas

Tumorsphere Derivation and Treatment from Primary Tumor Cells Isolated from Mouse Rhabdomyosarcomas

Published on: September 13, 2019

Genitourinary rhabdomyosarcoma: lessons from a developing-world series.

Richard Wood¹, John Lazarus, Alan Davidson

¹Red Cross Children's Hospital, Paediatric Surgery, Rondebosch 7701, South Africa.

Journal of Pediatric Surgery

|November 21, 2012

Summary

Pediatric genitourinary rhabdomyosarcoma in developing nations presents with more advanced disease. Improved surgical and oncological care since 1992 has significantly boosted survival rates for these children.

More Related Videos

Establishment of Cancer Stem Cell Cultures from Human Conventional Osteosarcoma

Establishment of Cancer Stem Cell Cultures from Human Conventional Osteosarcoma

Published on: October 14, 2016

An Orthotopic Bladder Cancer Model for Gene Delivery Studies

An Orthotopic Bladder Cancer Model for Gene Delivery Studies

Published on: December 1, 2013

Related Experiment Videos

Last Updated: May 16, 2026

Tumorsphere Derivation and Treatment from Primary Tumor Cells Isolated from Mouse Rhabdomyosarcomas

Tumorsphere Derivation and Treatment from Primary Tumor Cells Isolated from Mouse Rhabdomyosarcomas

Published on: September 13, 2019

Establishment of Cancer Stem Cell Cultures from Human Conventional Osteosarcoma

Establishment of Cancer Stem Cell Cultures from Human Conventional Osteosarcoma

Published on: October 14, 2016

An Orthotopic Bladder Cancer Model for Gene Delivery Studies

An Orthotopic Bladder Cancer Model for Gene Delivery Studies

Published on: December 1, 2013

Area of Science:

Pediatric Oncology
Surgical Oncology
Global Health

Background:

Genitourinary rhabdomyosarcoma (GU-RMS) is a rare pediatric malignancy.
Data from developing countries, particularly Africa, is limited.
Understanding disease presentation and outcomes is crucial for improving care.

Purpose of the Study:

To retrospectively review a large cohort of pediatric patients with GU-RMS from a developing country.
To analyze clinical presentation, demographics, and oncological management.
To compare outcomes before and after 1992.

Main Methods:

Retrospective review of 49 pediatric patients treated between 1961 and 2008.
Analysis included clinical presentation, demographics, surgical records, histology, and management.
Patients were grouped into pre-1992 and post-1992 treatment cohorts.

Main Results:

Median age at presentation was 3.5 years.
Most patients (59%) had locally advanced disease (Intergroup Rhabdomyosarcoma Study group 3).
Tumors >10 cm and positive lymph nodes were common (41% and 33%, respectively).
Overall survival was 65% (30/46).
Survival improved significantly for patients treated post-1992 (80% vs. 56%, P=.04).

Conclusions:

Pediatric GU-RMS in this African series presents with more advanced, bulky, and node-positive disease compared to developed nations.
Improvements in surgical and oncological care over the past two decades have enhanced survival for children with locally advanced GU-RMS.