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Updated: May 16, 2026

Functionalized Spirocyclic Heterocycle Synthesis and Cytotoxicity Assay
Published on: February 9, 2021
β-Lactam synthon-interceded diastereoselective synthesis of functionalized octahydroindole-based molecular scaffolds
Pardeep Singh1, Raghu Raj, Gaurav Bhargava
1Department of Chemistry, Guru Nanak Dev University, Amritsar 143005, India.
Abstract:
A convenient and unprecedented synthesis of functionally enriched octahydroindole-based scaffolds has been developed via inter- and intra-molecular amidolysis of C-3 functionalized β-lactams. The cytotoxic evaluation on oesophageal cancer cell line WHCO1 has revealed 7d as the most potent of the test compounds exhibiting an IC(50) value of 12.97 μM. The developed strategy further assumes significance as it entails the preparation of highly functionalized indoles without the aid of transition metal catalysis or pre-functionalization of substrates.
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