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Updated: May 16, 2026

Transport Properties of Ibuprofen Encapsulated in Cyclodextrin Nanosponge Hydrogels: A Proton HR-MAS NMR Spectroscopy Study
Published on: August 15, 2016
Relationship between surface properties determined by inverse gas chromatography and ibuprofen release from hybrid
Joanna Kołodziejek1, Eliza Główka, Kinga Hyla
1Poznan University of Technology, Institute of Chemical Technology and Engineering, Pl. M. Skłodowskiej-Curie 2, 60-965 Poznan, Poland. joannakolo@op.pl
Abstract:
The ability of organic-inorganic hybrid materials to act as drug release-modifying agents was examined. In this study, ibuprofen, a non-steroidal anti-inflammatory drug was used as a model active pharmaceutical ingredient. The physicochemical properties of individual components of the hybrids, as well as these for two- and three-component systems were examined by inverse gas chromatography. The dispersive component of the free surface energy (γ(S)(D)), K(A) and K(D) parameters describing acidity and basicity of hybrid materials, respectively, as well as Flory-Huggins parameters were determined. χ(12)(∞) and [Formula: see text] parameters characterize the interactions between the hybrids and a test solute, or interactions between the drug and inorganic-organic materials, respectively. Additionally, Brunauer-Emmett-Teller (BET) method was used to characterize adsorption activity of the studied materials. The prepared hybrid materials were also characterized by Fourier transform infra-red (FTIR) spectroscopy. The release profiles of ibuprofen for the created hybrid materials were determined. Relationship between the physicochemical activity of hybrid materials and ibuprofen release was presented and discussed.
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