Related Experiment Video
Updated: May 16, 2026
08:04
Murine Fetal Echocardiography
Published on: February 15, 2013
[Double outlet right ventricle. Embryological approach]
Luis Muñoz-Castellanos1, Magdalena Kuri
1Departamento de Embriología, Instituto Nacional de Cardiología Ignacio Chávez, México D.F., México. munoz-embriologia@hotmail.com
Archivos De Cardiologia De Mexico
|November 21, 2012
Summary
Double outlet right ventricle arises from persistent embryonic right ventricular outflow tract continuity. Anatomical variations result from progressive detortion and torsion of the truncoconal septum.
Area of Science:
- Congenital heart disease research
- Embryological development of the heart
- Cardiac morphology and anatomy
Context:
- Double outlet right ventricle (DORV) is a complex congenital heart defect.
- Understanding the morphogenesis of DORV anatomical variants is crucial for diagnosis and treatment.
- Previous explanations for DORV morphogenesis lacked detailed embryological correlation.
Purpose:
- To propose a pathogenetic explanation for the morphogenesis of anatomical variants of double outlet right ventricle.
- To correlate embryological development with the anatomical variations observed in DORV.
- To quantify the torsion of the truncoconal septum in different DORV subtypes.
Summary:
- A comparative anatomical embryological analysis was performed on 35 hearts with DORV.
- The study compared the truncoconal septum in DORV variants (slightly crossed, side-by-side, anterior aorta) with the normal embryonic heart.
- Truncoconal septum torsion was calculated, revealing specific degrees of rotation for each anatomical variant.
Impact:
- Provides a pathogenetic explanation for DORV based on embryological development.
- Elucidates the role of truncoconal septum detortion and torsion in creating DORV anatomical variations.
- Contributes to a deeper understanding of congenital heart defects, potentially aiding in future clinical management.
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