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Can atherosclerotic lesions regress? Angiographic evidence in humans
1Department of Medicine, University of Southern California School of Medicine, Los Angeles 90033.
The American Journal of Cardiology
|March 20, 1990
Insights
Atherosclerotic lesion regression is possible. Clinical trials using angiography show lesion stabilization, with one study providing clear evidence of regression in atherosclerosis.
Area of Science:
- Cardiovascular Science
- Medical Research
Background:
- Atherosclerosis is a significant cardiovascular disease.
- Evidence for lesion regression has been suggested by various studies.
Purpose of the Study:
- To evaluate the potential for atherosclerotic lesion regression.
- To analyze findings from clinical trials on atherosclerosis.
Main Methods:
- Review of autopsy findings in starved populations.
- Analysis of animal models with induced atherosclerosis.
- Examination of data from three angiographic clinical trials involving 317 subjects.
Main Results:
- Three angiographic trials demonstrated stabilization of atherosclerotic lesions.
- One trial provided clear evidence of atherosclerotic lesion regression.
Conclusions:
- Atherosclerotic lesions can stabilize and potentially regress.
- Angiography is a valuable tool for assessing lesion changes.
Abstract:
Evidence that atherosclerotic lesions can regress is derived from autopsy findings in starved human populations, animal-model studies of induced atherosclerosis, and clinical trials using angiography. Three angiographic trials, with a total of 317 subjects, have demonstrated stabilization of lesions. One of these trials has revealed clear evidence of lesion regression.