Related Experiment Video
Updated: May 16, 2026
07:15
A Mouse Model of Incompletely Resected Soft Tissue Sarcoma for Testing (Neo)adjuvant Therapies
Published on: July 28, 2020
Lessons from tumor reversion for cancer treatment
Robert Amson1, Judith E Karp, Adam Telerman
1CNRS-UMR 8113, LBPA, École Normale Supérieure, Cachan, France.
Current Opinion in Oncology
|November 21, 2012
Summary
Tumor reversion can reprogram malignant cells by targeting translationally controlled tumor protein (TPT1/TCTP). Decreasing TPT1/TCTP restores normal cell function and offers a new cancer treatment strategy.
Area of Science:
- Oncology
- Molecular Biology
- Cancer Research
Background:
- Tumor reversion involves the loss of malignant cell phenotypes.
- Understanding the molecular basis of tumor reversion is crucial for developing novel cancer therapies.
Purpose of the Study:
- To elucidate the molecular program underlying tumor reversion.
- To explore the clinical applications of tumor reversion strategies.
- To identify key genes and pathways involved in reversing the malignant phenotype.
Main Methods:
- Establishment of biological models of tumor reversion using derived revertant cells.
- Differential gene-expression profiling to identify implicated genes.
- Assessment of the molecular program overriding the malignant phenotype.
Main Results:
- Over 300 genes, including TPT1/TCTP, SIAH-1, PS1, and TSAP6, are implicated in tumor reversion.
- Decreasing TPT1/TCTP is critical for reprogramming malignant cells, including cancer stem cells.
- TPT1/TCTP regulates the P53-MDM2-Numb axis and is a prognostic factor in breast cancer.
- Sertraline and thioridazine target TPT1/TCTP, restoring wildtype p53 function.
Conclusions:
- Tumor reversion pathways represent a promising new avenue for cancer treatment.
- Targeting TPT1/TCTP offers a potential strategy for reprogramming cancer cells.
- Combination therapies involving TPT1/TCTP modulators may enhance treatment efficacy.
Related Concept Videos
01:27Tumor Immunotherapy
Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
02:40Cancer Stem Cells and Tumor Maintenance
Early diagnosis and treatment can often cure cancer. However, even with treatment, residual cells called cancer stem cells (CSC) might remain, often causing tumor recurrence. These cancer stem cells possess the potential for self-renewal and multi-lineage differentiation and are often responsible for the therapeutic resistance displayed in most cancers.
Cancer stem cells are thought to originate from tissue-specific normal stem cells or progenitor cells. The normal stem cells usually reside in...
Cancer stem cells are thought to originate from tissue-specific normal stem cells or progenitor cells. The normal stem cells usually reside in...
02:40Cancer Stem Cells and Tumor Maintenance
Early diagnosis and treatment can often cure cancer. However, even with treatment, residual cells called cancer stem cells (CSC) might remain, often causing tumor recurrence. These cancer stem cells possess the potential for self-renewal and multi-lineage differentiation and are often responsible for the therapeutic resistance displayed in most cancers.
Cancer stem cells are thought to originate from tissue-specific normal stem cells or progenitor cells. The normal stem cells usually reside in...
Cancer stem cells are thought to originate from tissue-specific normal stem cells or progenitor cells. The normal stem cells usually reside in...
02:56Treatment Resistent Cancers
Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...
02:56Treatment Resistant Cancers
Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...
02:18Cancer
Cancers arise due to mutations in genes involved in the regulation of cell division, which leads to unrestricted cell proliferation. Modern science and medicine have made great strides in the understanding and treatment of cancer, including eradicating cancer in some patients. However, there is still no cure for cancer. This is largely due to the fact that cancer is a large group of many diseases.