Related Experiment Video
Updated: May 16, 2026
Development of Compendium for Esophageal Squamous Cell Carcinoma
Published on: April 12, 2024
CCR7: A metastasis and prognosis indicator of postoperative patients with esophageal carcinoma
Background/Aims:
To investigate the expression of CC chemokine receptor 7 (CCR7) and its relationship to the metastasis and prognosis in esophageal squamous cell carcinoma (ESCC) after esophagectomy.
Methodology:
CCR7 expression was detected by immunohistochemistry. Kaplan-Meier method was performed to calculate the survival rate, Cox regression multivariate analysis was performed to determine independent prognostic factors.
Results:
CCR7 expression rate in T1, T2 and T3 patients was 27.3%, 64.7% and 75.2%, respectively, the difference of CCR7 protein expression was statistically significant (p=0.000). The positive expression of CCR7 in patients with lymph node metastasis was significantly higher than those without metastasis (p=0.000). CCR7 expression correlated with significantly worsened 5-year survival for all patients as well as those with T2 and T3 tumors, N0 nodal status or N1 nodal status. The result of Cox analysis demonstrated that N stage, T stage and CCR7 expression were independent prognostic factors.
Conclusions:
CCR7 expression was detected in ESCC and was found to be significantly associated with T stage and lymph node metastasis. The 5-year survival rate was significantly lower in patients with CCR7 expression in those without. Invasion, lymph node metastasis and CCR7 expression were independent factors.
