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Related Experiment Video

Updated: May 16, 2026

Renal Capsule Xenografting and Subcutaneous Pellet Implantation for the Evaluation of Prostate Carcinogenesis and Benign Prostatic Hyperplasia

Renal Capsule Xenografting and Subcutaneous Pellet Implantation for the Evaluation of Prostate Carcinogenesis and Benign Prostatic Hyperplasia

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The link between benign prostatic hyperplasia and prostate cancer.

David D Ørsted¹, Stig E Bojesen

¹54N5 Department of Clinical Biochemistry, Herlev Hospital, Copenhagen University Hospital, Herlev Ringvej 75, DK-2730 Herlev, Denmark.

Nature Reviews. Urology

|November 21, 2012

Summary

Benign prostatic hyperplasia (BPH) may increase the risk of prostate cancer. Further research is needed to determine if BPH causes prostate cancer, which could improve patient prognostication and reduce mortality.

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Area of Science:

Urology
Oncology
Pathophysiology

Background:

Benign prostatic hyperplasia (BPH) and prostate cancer are common prostate diseases with shared characteristics like hormone dependence.
Both conditions are influenced by risk factors such as prostate inflammation and metabolic disruption.
Despite similarities, BPH and prostate cancer differ in histology and localization.

Purpose of the Study:

To explore the association between benign prostatic hyperplasia (BPH) and an increased risk of prostate cancer.
To investigate whether the observed association between BPH and prostate cancer is causal, due to shared risk factors, or a result of detection bias.

Main Methods:

This study reviews epidemiological data and pathophysiological mechanisms linking BPH and prostate cancer.
Analysis considers shared risk factors, hormone-dependent growth, and response to antiandrogen therapy.

Main Results:

Epidemiological studies indicate a correlation between BPH and an elevated risk of prostate cancer and related mortality.
The precise nature of this association (causal, shared factors, or bias) requires further elucidation.

Conclusions:

Establishing a causal link between BPH and prostate cancer could enhance prognostic accuracy.
Identifying BPH as a causal factor may lead to earlier interventions and reduced prostate cancer mortality.