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Updated: May 16, 2026

Distinctive Capillary Action by Micro-channels in Bone-like Templates can Enhance Recruitment of Cells for Restoration of Large Bony Defect
Published on: September 11, 2015
The influence of environmental factors on bone tissue engineering
Caroline Szpalski1, Fabio Sagebin, Marissa Barbaro
1Department of Plastic Surgery, New York University Langone Medical Center, New York, New York, USA.
Abstract:
Bone repair and regeneration are dynamic processes that involve a complex interplay between the substrate, local and systemic cells, and the milieu. Although each constituent plays an integral role in faithfully recreating the skeleton, investigators have long focused their efforts on scaffold materials and design, cytokine and hormone administration, and cell-based therapies. Only recently have the intangible aspects of the milieu received their due attention. In this review, we highlight the important influence of environmental factors on bone tissue engineering.
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