Related Experiment Video
Updated: May 16, 2026

An Integrated Approach for Microprotein Identification and Sequence Analysis
Published on: July 12, 2022
Computational approaches to predicting essential proteins: a survey
Jianxin Wang1, Wei Peng, Fang-Xiang Wu
1School of Information Science and Engineering, Central South University, Changsha, China. jxwang@mail.csu.edu.cn
Abstract:
Essential proteins are indispensable to support cellular life. Identifying essential proteins can help us understand the minimal requirements for cell survival, which plays a significant role in the emerging field of synthetic biology. Moreover, essential proteins also serve as candidates of drug targets for developing novel therapy of diseases, such as cancer or infectious disease caused by emerging pathogens. However, it is expensive and time consuming to experimentally identify essential proteins. With accumulation of sequenced genomes, the gap between genome-wide essential protein data and sequence data become increasingly wide. Thus, computational approaches for detecting essential proteins are useful complements to limited experimental methods. There are many features related to protein essentiality. By taking advantage of these features, many computational approaches have been proposed to identify essential proteins. In this paper, we review the state-of-the-art techniques for computational detection of essential proteins, and discuss some challenges for future research in this field.
More Related Videos
Related Concept Videos
Protein-protein Interfaces
Protein Networks
These interactions can be represented through maps depicting protein-protein interaction networks, represented as nodes and edges. Nodes are circles that are representative of a protein,...
Protein Networks
These interactions can be represented through maps depicting protein-protein interaction networks, represented as nodes and edges. Nodes are circles that are representative of a protein,...
Conserved Binding Sites
Binding sites are often located in large pockets, and if their location on a protein’s surface is unknown, it can be predicted using various approaches. The energetic method computationally analyses the...
Conservation of Protein Domains Over Different Proteins
A limited set of protein domains often duplicate and recombine during evolution. These domains can be organized in different combinations to form...
Protein Organization
The primary structure of a protein is its amino acid sequence.

