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Procedure for Fabricating Biofunctional Nanofibers
Published on: September 10, 2012
Polyacrylonitrile nanofibers coated with silver nanoparticles using a modified coaxial electrospinning process
Deng-Guang Yu1, Jie Zhou, Nicholas P Chatterton
1School of Materials Science and Engineering, University of Shanghai for Science and Technology, Shanghai, People's Republic of China.
International Journal of Nanomedicine
|November 21, 2012
Summary
This study developed novel antibacterial nanofibers coated with silver nanoparticles (AgNPs) using coaxial electrospinning. The AgNP-coated nanofibers demonstrated significant antimicrobial activity against common bacteria.
Area of Science:
- Materials Science
- Nanotechnology
- Biomedical Engineering
Background:
- Developing advanced antibacterial materials is crucial for combating infections.
- Silver nanoparticles (AgNPs) exhibit potent antimicrobial properties.
- Controlling AgNP distribution on material surfaces can enhance efficacy.
Purpose of the Study:
- To create a new class of antibacterial material using nanofibers coated with AgNPs.
- To improve the antibacterial effect of silver through surface distribution manipulation.
- To utilize a modified coaxial electrospinning technique for material fabrication.
Main Methods:
- Polyacrylonitrile (PAN) solution was used as the core fluid.
- Silver nitrate (AgNO₃) solution served as the sheath fluid in coaxial electrospinning.
- Varied sheath-to-core flow rate ratios were employed to control nanofiber characteristics.
Main Results:
- Coaxial electrospinning significantly reduced nanofiber diameters.
- AgNPs were effectively distributed on the surface of polyacrylonitrile (PAN) nanofibers.
- The AgNP-coated nanofibers exhibited strong antimicrobial activity against Bacillus subtilis and Escherichia coli.
Conclusions:
- Modified coaxial electrospinning facilitates nanofiber production and surface functionalization with AgNPs.
- Surface-localized AgNPs enhance the antibacterial activity of the nanofibers.
- This methodology offers a systematic approach for designing and preparing novel antibacterial nanomaterials.
